Friday, December 23, 2022

Peace on Earth, Good Will to Men 2022

When asked what I want for Christmas, I reply: Peace On Earth, Good Will To Men :-)

No one ever seems to recognize that this comes from the Bible (Luke 2.14).

Linus said it best in A Charlie Brown Christmas:
And there were in the same country shepherds abiding in the field, keeping watch over their flock by night.

And, lo, the angel of the Lord came upon them, and the glory of the Lord shone round about them: and they were sore afraid.

And the angel said unto them, Fear not: for, behold, I bring you good tidings of great joy, which shall be to all people.

For unto you is born this day in the city of David a Saviour, which is Christ the Lord.

And this shall be a sign unto you; Ye shall find the babe wrapped in swaddling clothes, lying in a manger.

And suddenly there was with the angel a multitude of the heavenly host praising God, and saying,

Glory to God in the highest, and on earth peace, good will toward men.

Merry Christmas!

Please accept my best wishes and hopes for a wonderful 2023. Be of good cheer, for we shall prevail! :-) 

The first baby conceived from an embryo screened with Genomic Prediction preimplantation genetic testing for polygenic risk scores (PGT-P) was born in mid-2020. 

First Baby Born from a Polygenically Screened Embryo (video panel)

Embryo Screening for Polygenic Disease Risk: Recent Advances and Ethical Considerations (Genes 2021 Special Issue)
It is a great honor to co-author a paper with Simon Fishel, a member of the team that produced the first IVF baby (Louise Brown) in 1978. His mentors and collaborators were Robert Edwards (Nobel Prize 2010) and Patrick Steptoe (passed before 2010). ... 
Today millions of babies are produced through IVF. In most developed countries roughly 3-5 percent of all births are through IVF, and in Denmark the fraction is about 10 percent! But when the technology was first introduced with the birth of Louise Brown in 1978, the pioneering scientists had to overcome significant resistance. 
There may be an alternate universe in which IVF was not allowed to develop, and those millions of children were never born. 
Wikipedia: ...During these controversial early years of IVF, Fishel and his colleagues received extensive opposition from critics both outside of and within the medical and scientific communities, including a civil writ for murder.[16] Fishel has since stated that "the whole establishment was outraged" by their early work and that people thought that he was "potentially a mad scientist".[17] 
I predict that within 5 years the use of polygenic risk scores will become common in health systems (i.e., for adults) and in IVF. Reasonable people will wonder why the technology was ever controversial at all, just as in the case of IVF.

GP highlights from 2022:

Genomic Prediction has performed embryo genetic tests for  ~200 IVF clinics on six continents: nearly ~30k embryos have been screened.

Genomic Prediction in Bloomberg 

Preimplantation Genetic Testing for Aneuploidy: New Methods and Higher Pregnancy Rates

Seven years ago on Christmas day I shared the Nativity 2050 story below. 

And the angel said unto them, Fear not: for, behold, I bring you good tidings of great joy, which shall be to all people.
Mary was born in the twenties, when the tests were new and still primitive. Her mother had frozen a dozen eggs, from which came Mary and her sister Elizabeth. Mary had her father's long frame, brown eyes, and friendly demeanor. She was clever, but Elizabeth was the really brainy one. Both were healthy and strong and free from inherited disease. All this her parents knew from the tests -- performed on DNA taken from a few cells of each embryo. The reports came via email, from GP Inc., by way of the fertility doctor. Dad used to joke that Mary and Elizabeth were the pick of the litter, but never mentioned what happened to the other fertilized eggs.

Now Mary and Joe were ready for their first child. The choices were dizzying. Fortunately, Elizabeth had been through the same process just the year before, and referred them to her genetic engineer, a friend from Harvard. Joe was a bit reluctant about bleeding edge edits, but Mary had a feeling the GP engineer was right -- their son had the potential to be truly special, with just the right tweaks ...

Bonus: My Christmas present to you! (For Jazz fans!)


Photo from Before Sunrise

00:00 Miles Davis Quintet - When I Fall In Love 
04:23 Red Garland - When I Fall In Love 
09:30 Bill Evans Trio - When I Fall In Love 
14:25 Kenichi Fujiwara - When I Fall In Love 
22:06 Blue Mitchell - When I Fall In Love 
27:46 George Coleman - When I Fall In Love 
38:42 Ben Webster - When I Fall In Love 
43:39 Johnny Smith Trio - When I Fall In Love 
46:27 Oscar Peterson Trio - When I Fall In Love 
51:34 Brad Mehldau & Rossy Trio - When I Fall In Love (Live) 

🎙 vocal (female) 
01:06:13 Carmen McRae - When I Fall In Love [vocal] 
01:10:02 Etta Jones - When I Fall In Love [vocal] 
01:12:56 Marilyn Monroe - When I Fall In Love [vocal] 
01:15:55 Linda Ronstadt - When I Fall In Love [vocal] 
01:18:17 Barbar Gough - When I Fall In Love [vocal] 
01:21:18 Julie London - When I Fall In Love [vocal] 
01:24:40 Trijntje Oosterhuis - When I Fall In Love [vocal] 

 ðŸŽ™ vocal (male) 
01:29:27 Chet Baker - When I Fall In Love [vocal] 
01:33:01 Nat King Cole - When I Fall In Love [vocal] 
01:36:12 Tony Bennett - When I Fall In Love [vocal] 
01:38:30 Michael Buble - When I Fall In Love [vocal] 
01:41:26 José James - When I Fall In Love [vocal] (piano. Jef Neve) 
01:46:40 Donny Osmond - When I Fall In Love [vocal] 

 ðŸŽ™ vocal (duet) 
01:49:55 Celine Dion & Clive Griffin - When I Fall In Love [vocal] 
01:54:16 Natalie Cole & Nat King Cole - When I Fall In Love [vocal]

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