Nature: ... He found out about a process called preimplantation genetic diagnosis or PGD. By conceiving through in vitro fertilization (IVF) and screening the embryos, Carroll and his wife could all but eliminate the chance of passing on the mutation. They decided to give it a shot, and had twins free of the Huntington’s mutation in 2006.
Now Carroll is a researcher at Western Washington University in Bellingham, where he uses another technique that might help couples in his position: CRISPR gene editing. He has been using the powerful tool to tweak expression of the gene responsible for Huntington’s disease in mouse cells. Because it is caused by a single gene and is so devastating, Huntington’s is sometimes held up as an example of a condition in which gene editing a human embryo — controversial because it would cause changes that would be inherited by future generations — could be really powerful. But the prospect of using CRISPR to alter the gene in human embryos still worries Carroll. “That’s a big red line,” he says. “I get that people want to go over it — I do, too. But we have to be super humble about this stuff.” There could be many unintended consequences, both for the health of individuals and for society. It would take decades of research, he says, before the technology could be used safely.
Pessimism of the Intellect, Optimism of the Will Favorite posts | Manifold podcast | Twitter: @hsu_steve
Thursday, June 20, 2019
CRISPR babies: when will the world be ready? (Nature)
This Nature News article gives a nice overview of the current status of CRISPR technology and its potential application in human reproduction. As we discussed in this bioethics conversation (Manifold Podcast #9 with philosopher Sam Kerstein of the University of Maryland), it is somewhat challenging to come up with examples where gene editing is favored over embryo selection (a well-established technology) for avoidance of a disease-linked mutation.
Subscribe to:
Post Comments (Atom)
Blog Archive
-
▼
2019
(113)
-
▼
06
(9)
- Manifold Podcast #13: Joe Cesario on Political Bia...
- Ulam on von Neumann, Godel, and Einstein
- Silicon Oligarchs: Winner Take All?
- CRISPR babies: when will the world be ready? (Nature)
- Manifold Episode #12: James Cham on Venture Capita...
- Validation of Polygenic Risk Scores for Coronary A...
- L1 vs Deep Learning in Genomic Prediction
- London: CogX, Founders Forum, Healthtech
- Genomic Prediction: Polygenic Risk Score for Type ...
-
▼
06
(9)
Labels
- physics (420)
- genetics (325)
- globalization (301)
- genomics (295)
- technology (282)
- brainpower (280)
- finance (275)
- american society (261)
- China (249)
- innovation (231)
- ai (206)
- economics (202)
- psychometrics (190)
- science (172)
- psychology (169)
- machine learning (166)
- biology (163)
- photos (162)
- genetic engineering (150)
- universities (150)
- travel (144)
- podcasts (143)
- higher education (141)
- startups (139)
- human capital (127)
- geopolitics (124)
- credit crisis (115)
- political correctness (108)
- iq (107)
- quantum mechanics (107)
- cognitive science (103)
- autobiographical (97)
- politics (93)
- careers (90)
- bounded rationality (88)
- social science (86)
- history of science (85)
- realpolitik (85)
- statistics (83)
- elitism (81)
- talks (80)
- evolution (79)
- credit crunch (78)
- biotech (76)
- genius (76)
- gilded age (73)
- income inequality (73)
- caltech (68)
- books (64)
- academia (62)
- history (61)
- intellectual history (61)
- MSU (60)
- sci fi (60)
- harvard (58)
- silicon valley (58)
- mma (57)
- mathematics (55)
- education (53)
- video (52)
- kids (51)
- bgi (48)
- black holes (48)
- cdo (45)
- derivatives (43)
- neuroscience (43)
- affirmative action (42)
- behavioral economics (42)
- economic history (42)
- literature (42)
- nuclear weapons (42)
- computing (41)
- jiujitsu (41)
- physical training (40)
- film (39)
- many worlds (39)
- quantum field theory (39)
- expert prediction (37)
- ufc (37)
- bjj (36)
- bubbles (36)
- mortgages (36)
- google (35)
- race relations (35)
- hedge funds (34)
- security (34)
- von Neumann (34)
- meritocracy (31)
- feynman (30)
- quants (30)
- taiwan (30)
- efficient markets (29)
- foo camp (29)
- movies (29)
- sports (29)
- music (28)
- singularity (27)
- entrepreneurs (26)
- conferences (25)
- housing (25)
- obama (25)
- subprime (25)
- venture capital (25)
- berkeley (24)
- epidemics (24)
- war (24)
- wall street (23)
- athletics (22)
- russia (22)
- ultimate fighting (22)
- cds (20)
- internet (20)
- new yorker (20)
- blogging (19)
- japan (19)
- scifoo (19)
- christmas (18)
- dna (18)
- gender (18)
- goldman sachs (18)
- university of oregon (18)
- cold war (17)
- cryptography (17)
- freeman dyson (17)
- smpy (17)
- treasury bailout (17)
- algorithms (16)
- autism (16)
- personality (16)
- privacy (16)
- Fermi problems (15)
- cosmology (15)
- happiness (15)
- height (15)
- india (15)
- oppenheimer (15)
- probability (15)
- social networks (15)
- wwii (15)
- fitness (14)
- government (14)
- les grandes ecoles (14)
- neanderthals (14)
- quantum computers (14)
- blade runner (13)
- chess (13)
- hedonic treadmill (13)
- nsa (13)
- philosophy of mind (13)
- research (13)
- aspergers (12)
- climate change (12)
- harvard society of fellows (12)
- malcolm gladwell (12)
- net worth (12)
- nobel prize (12)
- pseudoscience (12)
- Einstein (11)
- art (11)
- democracy (11)
- entropy (11)
- geeks (11)
- string theory (11)
- television (11)
- Go (10)
- ability (10)
- complexity (10)
- dating (10)
- energy (10)
- football (10)
- france (10)
- italy (10)
- mutants (10)
- nerds (10)
- olympics (10)
- pop culture (10)
- crossfit (9)
- encryption (9)
- eugene (9)
- flynn effect (9)
- james salter (9)
- simulation (9)
- tail risk (9)
- turing test (9)
- alan turing (8)
- alpha (8)
- ashkenazim (8)
- data mining (8)
- determinism (8)
- environmentalism (8)
- games (8)
- keynes (8)
- manhattan (8)
- new york times (8)
- pca (8)
- philip k. dick (8)
- qcd (8)
- real estate (8)
- robot genius (8)
- success (8)
- usain bolt (8)
- Iran (7)
- aig (7)
- basketball (7)
- free will (7)
- fx (7)
- game theory (7)
- hugh everett (7)
- inequality (7)
- information theory (7)
- iraq war (7)
- markets (7)
- paris (7)
- patents (7)
- poker (7)
- teaching (7)
- vietnam war (7)
- volatility (7)
- anthropic principle (6)
- bayes (6)
- class (6)
- drones (6)
- econtalk (6)
- empire (6)
- global warming (6)
- godel (6)
- intellectual property (6)
- nassim taleb (6)
- noam chomsky (6)
- prostitution (6)
- rationality (6)
- academia sinica (5)
- bobby fischer (5)
- demographics (5)
- fake alpha (5)
- kasparov (5)
- luck (5)
- nonlinearity (5)
- perimeter institute (5)
- renaissance technologies (5)
- sad but true (5)
- software development (5)
- solar energy (5)
- warren buffet (5)
- 100m (4)
- Poincare (4)
- assortative mating (4)
- bill gates (4)
- borges (4)
- cambridge uk (4)
- censorship (4)
- charles darwin (4)
- computers (4)
- creativity (4)
- hormones (4)
- humor (4)
- judo (4)
- kerviel (4)
- microsoft (4)
- mixed martial arts (4)
- monsters (4)
- moore's law (4)
- soros (4)
- supercomputers (4)
- trento (4)
- 200m (3)
- babies (3)
- brain drain (3)
- charlie munger (3)
- cheng ting hsu (3)
- chet baker (3)
- correlation (3)
- ecosystems (3)
- equity risk premium (3)
- facebook (3)
- fannie (3)
- feminism (3)
- fst (3)
- intellectual ventures (3)
- jim simons (3)
- language (3)
- lee kwan yew (3)
- lewontin fallacy (3)
- lhc (3)
- magic (3)
- michael lewis (3)
- mit (3)
- nathan myhrvold (3)
- neal stephenson (3)
- olympiads (3)
- path integrals (3)
- risk preference (3)
- search (3)
- sec (3)
- sivs (3)
- society generale (3)
- systemic risk (3)
- thailand (3)
- twitter (3)
- alibaba (2)
- bear stearns (2)
- bruce springsteen (2)
- charles babbage (2)
- cloning (2)
- david mamet (2)
- digital books (2)
- donald mackenzie (2)
- drugs (2)
- dune (2)
- exchange rates (2)
- frauds (2)
- freddie (2)
- gaussian copula (2)
- heinlein (2)
- industrial revolution (2)
- james watson (2)
- ltcm (2)
- mating (2)
- mba (2)
- mccain (2)
- monkeys (2)
- national character (2)
- nicholas metropolis (2)
- no holds barred (2)
- offices (2)
- oligarchs (2)
- palin (2)
- population structure (2)
- prisoner's dilemma (2)
- singapore (2)
- skidelsky (2)
- socgen (2)
- sprints (2)
- star wars (2)
- ussr (2)
- variance (2)
- virtual reality (2)
- war nerd (2)
- abx (1)
- anathem (1)
- andrew lo (1)
- antikythera mechanism (1)
- athens (1)
- atlas shrugged (1)
- ayn rand (1)
- bay area (1)
- beats (1)
- book search (1)
- bunnie huang (1)
- car dealers (1)
- carlos slim (1)
- catastrophe bonds (1)
- cdos (1)
- ces 2008 (1)
- chance (1)
- children (1)
- cochran-harpending (1)
- cpi (1)
- david x. li (1)
- dick cavett (1)
- dolomites (1)
- eharmony (1)
- eliot spitzer (1)
- escorts (1)
- faces (1)
- fads (1)
- favorite posts (1)
- fiber optic cable (1)
- francis crick (1)
- gary brecher (1)
- gizmos (1)
- greece (1)
- greenspan (1)
- hypocrisy (1)
- igon value (1)
- iit (1)
- inflation (1)
- information asymmetry (1)
- iphone (1)
- jack kerouac (1)
- jaynes (1)
- jazz (1)
- jfk (1)
- john dolan (1)
- john kerry (1)
- john paulson (1)
- john searle (1)
- john tierney (1)
- jonathan littell (1)
- las vegas (1)
- lawyers (1)
- lehman auction (1)
- les bienveillantes (1)
- lowell wood (1)
- lse (1)
- machine (1)
- mcgeorge bundy (1)
- mexico (1)
- michael jackson (1)
- mickey rourke (1)
- migration (1)
- money:tech (1)
- myron scholes (1)
- netwon institute (1)
- networks (1)
- newton institute (1)
- nfl (1)
- oliver stone (1)
- phil gramm (1)
- philanthropy (1)
- philip greenspun (1)
- portfolio theory (1)
- power laws (1)
- pyschology (1)
- randomness (1)
- recession (1)
- sales (1)
- skype (1)
- standard deviation (1)
- starship troopers (1)
- students today (1)
- teleportation (1)
- tierney lab blog (1)
- tomonaga (1)
- tyler cowen (1)
- venice (1)
- violence (1)
- virtual meetings (1)
- wealth effect (1)
No comments:
Post a Comment