Here's an excerpt about how the "invention" process works -- get some smart guys in a room and let them talk (every theory group lounge is a fount of commercializable ideas ;-). Yes! if your inventors are smart enough, they can produce 36 new inventions at dinner! Is this a statement about real innovation, or about what a patent attorney might manage to get the understaffed, overburdened USPTO to approve? It makes a mockery of what real inventors and innovators do. Why start a company and hire engineers to build a prototype? Just get a few lawyers and patent everything in sight...
How useful is it to have a group of really smart people brainstorm for a day? When Myhrvold started out, his expectations were modest. Although he wanted insights like Alexander Graham Bell’s, Bell was clearly one in a million, a genius who went on to have ideas in an extraordinary number of areas—sound recording, flight, lasers, tetrahedral construction, and hydrofoil boats, to name a few. ...
But then, in August of 2003, I.V. held its first invention session, and it was a revelation. “Afterward, Nathan kept saying, ‘There are so many inventions,’ ” Wood recalled. “He thought if we came up with a half-dozen good ideas it would be great, and we came up with somewhere between fifty and a hundred. I said to him, ‘But you had eight people in that room who are seasoned inventors. Weren’t you expecting a multiplier effect?’ And he said, ‘Yeah, but it was more than multiplicity.’ Not even Nathan had any idea of what it was going to be like.”
The original expectation was that I.V. would file a hundred patents a year. Currently, it’s filing five hundred a year. It has a backlog of three thousand ideas. Wood said that he once attended a two-day invention session presided over by Jung, and after the first day the group went out to dinner. “So Edward took his people out, plus me,” Wood said. “And the eight of us sat down at a table and the attorney said, ‘Do you mind if I record the evening?’ And we all said no, of course not. We sat there. It was a long dinner. I thought we were lightly chewing the rag. But the next day the attorney comes up with eight single-spaced pages flagging thirty-six different inventions from dinner. Dinner.”
For the cognoscenti out there, yes, the Wood mentioned in the article is none other than Star Warrior Lowell Wood, former head of the zany (useless?) O Group (NYTimes 1984) at Livermore. Wood is perfect for Myhrvold's purposes -- for decades his group bamboozled the US defense establishment with wild ideas that cost taxpayers billions of dollars. Follow the link to the Times article and tell me how many of the ideas mentioned turned into something useful, now almost a quarter century later.
Rather than leave you with a completely negative impression of the article, I include the following excerpt, which has Wood noticing something about cancer cells in the bloodstream that seems to have eluded biologists and medical researchers for some time. It is true that there are great ideas out there just waiting to be discovered, but lots of people can have the same idea. The hard part is making the idea into a practical, commercially viable reality.
...Last March, Myhrvold decided to do an invention session with Eric Leuthardt and several other physicians in St. Louis. Rod Hyde came, along with a scientist from M.I.T. named Ed Boyden. Wood was there as well.
“Lowell came in looking like the Cheshire Cat,” Myhrvold recalled. “He said, ‘I have a question for everyone. You have a tumor, and the tumor becomes metastatic, and it sheds metastatic cancer cells. How long do those circulate in the bloodstream before they land?’ And we all said, ‘We don’t know. Ten times?’ ‘No,’ he said. ‘As many as a million times.’ Isn’t that amazing? If you had no time, you’d be screwed. But it turns out that these cells are in your blood for as long as a year before they land somewhere. What that says is that you’ve got a chance to intercept them.”
How did Wood come to this conclusion? He had run across a stray fact in a recent issue of The New England Journal of Medicine. “It was an article that talked about, at one point, the number of cancer cells per millilitre of blood,” he said. “And I looked at that figure and said, ‘Something’s wrong here. That can’t possibly be true.’ The number was incredibly high. Too high. It has to be one cell in a hundred litres, not what they were saying—one cell in a millilitre. Yet they spoke of it so confidently. I clicked through to the references. It was a commonplace. There really were that many cancer cells.”
Wood did some arithmetic. He knew that human beings have only about five litres of blood. He knew that the heart pumps close to a hundred millilitres of blood per beat, which means that all of our blood circulates through our bloodstream in a matter of minutes. The New England Journal article was about metastatic breast cancer, and it seemed to Wood that when women die of metastatic breast cancer they don’t die with thousands of tumors. The vast majority of circulating cancer cells don’t do anything.
“It turns out that some small per cent of tumor cells are actually the deadly ones,” he went on. “Tumor stem cells are what really initiate metastases. And isn’t it astonishing that they have to turn over at least ten thousand times before they can find a happy home? You naïvely think it’s once or twice or three times. Maybe five times at most. It isn’t. In other words, metastatic cancer—the brand of cancer that kills us—is an amazingly hard thing to initiate. Which strongly suggests that if you tip things just a little bit you essentially turn off the process.”
That was the idea that Wood presented to the room in St. Louis. From there, the discussion raced ahead. Myhrvold and his inventors had already done a lot of thinking about using tiny optical filters capable of identifying and zapping microscopic particles. They also knew that finding cancer cells in blood is not hard. They’re often the wrong size or the wrong shape. So what if you slid a tiny filter into a blood vessel of a cancer patient? “You don’t have to intercept very much of the blood for it to work,” Wood went on. “Maybe one ten-thousandth of it. The filter could be put in a little tiny vein in the back of the hand, because that’s all you need. Or maybe I intercept all of the blood, but then it doesn’t have to be a particularly efficient filter.”
Wood was a physicist, not a doctor, but that wasn’t necessarily a liability, at this stage. “People in biology and medicine don’t do arithmetic,” he said. He wasn’t being critical of biologists and physicians: this was, after all, a man who read medical journals for fun. He meant that the traditions of medicine encouraged qualitative observation and interpretation. But what physicists do—out of sheer force of habit and training—is measure things and compare measurements, and do the math to put measurements in context. At that moment, while reading The New England Journal, Wood had the advantages of someone looking at a familiar fact with a fresh perspective.
That was also why Myhrvold had wanted to take his crew to St. Louis to meet with the surgeons. He likes to say that the only time a physicist and a brain surgeon meet is when the physicist is about to be cut open—and to his mind that made no sense. Surgeons had all kinds of problems that they didn’t realize had solutions, and physicists had all kinds of solutions to things that they didn’t realize were problems. At one point, Myhrvold asked the surgeons what, in a perfect world, would make their lives easier, and they said that they wanted an X-ray that went only skin deep. They wanted to know, before they made their first incision, what was just below the surface. When the Intellectual Ventures crew heard that, their response was amazement. “That’s your dream? A subcutaneous X-ray? We can do that.”
Let me close with my usual observation (specifically aimed at venture capitalists, research lab directors and university administrators) concerning an asymmetry in cognitive depth: yes, physicists can casually read the New England Journal of Medicine and come up with interesting insights, but, no, biologists and medical doctors cannot read Physical Review.