Many scientific entrepreneurs reject any notion that the transformation of knowledge into material products or marketable services is any less intellectually demanding, or that it requires any lesser degree of intelligence, than so called pure science. ... The problems may be diffusely framed -- how to raise finance, recruit and motivate people, organize the corporate environment, locate markets and identify competitors -- but, because of that, they can plausibly be seen as more intellectually demanding than the well-framed problems of academic science. Entrepreneurs may see themselves as having a broad vision of the world, contrasted to the narrowness and inwardness of their purely academic colleagues. They know how to do things about which their colleagues are clueless. It's a matter of experience, of course, but it may also be seen as a form of constitutional intelligence.
While I can't help but like this paragraph, I do think we should distinguish between intellectual ability and other sorts of abilities. Scientists who start and run companies may have a broader set of skills (leadership, negotiation, risk taking, communication, psychological insight, etc.) than the typical academic, but I wouldn't describe running a startup as more intellectually demanding than pure scientific research (at least not theoretical physics!).