Thursday, February 03, 2022

ManifoldOne podcast Episode#2: Steve Hsu Q&A


Steve answers questions about recent progress in AI/ML prediction of complex traits from DNA, and applications in embryo selection. 


1. Overview of recent advances in trait prediction 
2. Would cost savings from breast cancer early detection pay for genotyping of all women? 
3. How does IVF work? Economics of embryo selection 
4. Whole embryo genotyping increases IVF success rates (pregnancy per transfer) significantly 
5. Future predictions 

Some relevant scientific papers: 

Preimplantation Genetic Testing for Aneuploidy: New Methods and Higher Pregnancy Rates 

2021 review article on complex trait prediction 

Accurate Genomic Prediction of Human Height 

Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer 

Genetic architecture of complex traits and disease risk predictors 

Sibling validation of polygenic risk scores and complex trait prediction 

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