ManifoldOne Podcast Episode #5: Shai Carmi (Hebrew University): Polygenic risk scores & embryo screening

 

Shai Carmi is Professor of Statistical and Medical Genetics at Hebrew University (Jerusalem). 

Carmi Lab: https://scarmilab.org/ 

Twitter: https://twitter.com/ShaiCarmi 

Topics and links: 

1. Shai's educational background. From statistical physics and network theory to genomics. 

2. Shai's paper on embryo selection: Schizophrenia risk. Modeling synthetic sibling genomes. Variance among sibs vs general population. RRR vs ARR, family history and elevated polygenic risk. 

https://www.biorxiv.org/content/10.1101/2020.11.05.370478v3 

3. Response to the ESHG opinion piece on embryo selection. https://twitter.com/ShaiCarmi/status/1487694576458481664 

4. Pleiotropy, Health Index scores. 

5. Genetic genealogy and DNA forensics. Solving cold cases, Othram, etc.  https://www.science.org/doi/10.1126/science.aau4832

6. Healthcare in Israel. Application of PRS in adult patients.

ManifoldOne podcast (transcript).