tag:blogger.com,1999:blog-5880610.post1142682124216771376..comments2024-01-13T18:57:18.243-05:00Comments on Information Processing: Rare variants and human genetic diversitySteve Hsuhttp://www.blogger.com/profile/02428333897272913660noreply@blogger.comBlogger14125tag:blogger.com,1999:blog-5880610.post-43212072292393480712012-07-25T18:12:49.068-04:002012-07-25T18:12:49.068-04:00"when environmental change is occurring more ..."when environmental change is occurring more rapidly than evolutionary <br />change (which I would argue has been the case for the last few thousand <br />years and especially for the last few hundred years)"<br /><br />I agree but am not sure I can draw any conclusions. If I understand Steve's results it appears that despite very rapid (in evolutionary terms) cultural change, over MtMorunoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-25177914507905258602012-07-25T00:18:22.692-04:002012-07-25T00:18:22.692-04:00Perhaps it would be more accurate to say non-advan...Perhaps it would be more accurate to say non-advantageous (i.e. not conferring a fitness advantage in the current environment). If a variant is advantageous it should become less rare (has the relative rate of positive and negative selection been established?). I definitely agree with you about "the deleteriousness may vary from one environment and society to another" (I think I have Richard Seiternoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-23651795003513648542012-07-24T22:53:00.738-04:002012-07-24T22:53:00.738-04:00Intrinsically deleterious? Or accidentally deleter...Intrinsically deleterious? Or accidentally deleterious? There is a difference.MtMorunoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-65687824370744322122012-07-24T22:52:26.363-04:002012-07-24T22:52:26.363-04:00Right, but deleterious how? Without any overt unmi...Right, but deleterious how? Without any overt unmistakable pathology the deleteriousness may vary from one environment and society to another.<br /><br />I will keep beating my dead horse.MtMorunoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-79074500257716879552012-07-23T23:55:48.686-04:002012-07-23T23:55:48.686-04:00Don't be silly Steve.
latitude is correlated ...Don't be silly Steve.<br /><br />latitude is correlated with length of human habitation. Europe and Siberia and America and so forth were settled only after humans had been in Africa for 100k years or so.MtMorunoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-74267951017357620102012-07-14T10:55:55.187-04:002012-07-14T10:55:55.187-04:00It makes sense that the majority of rare variants ...It makes sense that the majority of rare variants would be deleterious. Rare variants might be more likely to be advantageous for traits which are not likely to have been selected for, but that most people would consider beneficial. I think this is a good example: <br />http://www.nature.com/news/gene-mutation-defends-against-alzheimer-s-disease-1.10984 What sorts of examples of other Richard Seiternoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-60556886146533550872012-07-13T10:58:34.981-04:002012-07-13T10:58:34.981-04:00Considering the irresponsibly out of control rate ...Considering the irresponsibly out of control rate at which these negroes breed, of course you'll see a certain amount of variation. <br />I wonder how many centuries we'll have to wait before we see a mutation that can plan ahead, hold down a job or refrain from illegal behavior?finkgermanicusnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-74584058669344226042012-07-12T00:46:57.587-04:002012-07-12T00:46:57.587-04:00Not sure I understand why common variants couldn&#...Not sure I understand why common variants couldn't be the cause of human differences either? I thought the current thinking was that differences in complex traits were due to a combination of lots of small effect common variants plus larger effect rare variants? So wouldn't the true level of relevant genetic variance be somewhere between the number we derive from rare variants and the ben_gnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-87709447787691430262012-07-09T22:15:23.408-04:002012-07-09T22:15:23.408-04:00blonde and red hair, blue and green eyes, pink nip...blonde and red hair, blue and green eyes, pink nipples are found only in white women. And magazine covers show their alluring beauty. Some East Asians have milky white skin, but no variation in hair or eyes. That's one physical trait that makes White people special and White women the standard of beauty. <br /><br />But low birth rates and mass immigration is designed to exterminate Freedom Fighterhttp://theoccidentalobserver.net/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-81991303733522059602012-07-09T12:23:57.388-04:002012-07-09T12:23:57.388-04:00Ultimately "genetic diversity" is just a...Ultimately "genetic diversity" is just a proxy for things we really want to know, like the distribution of actual causal variants.<br /><br />Although no one knows for sure, it seems likely that the vast majority of rare variants will be deleterious. See my BGA talk slides for an evolutionary argument: the basic idea that a random mutation is more likely to hurt than help; those that dosteve hsuhttp://duende.uoregon.edu/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-4292584468977194522012-07-09T11:21:27.298-04:002012-07-09T11:21:27.298-04:00Is the number of rare variants the accepted measur...Is the number of rare variants the accepted measure of genetic diversity? It seems like a measure of population diversity should also account for the number of individuals possessing each variant. I understand that rare variants are a very relevant measure for the IQ study (if I understand correctly, the number of variants provide the raw material for the variation which determines how much youRichard Seiternoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-9139575717302237672012-07-09T09:44:27.202-04:002012-07-09T09:44:27.202-04:00I was once told by a friend in Japan that within t...I was once told by a friend in Japan that within the population in Japan there is a greater degree of genetic diversity that within any other Asian ethnic group. I have no idea if this is correct or, if it is, what would account for the diversity. I remember we speculated about different waves of immigrants arriving on top of the indigenous population and then being subject to long periods of Michael Baconhttp://www.facebook.com/people/Michael-Bacon/1316725989noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-70075892681244963492012-07-09T01:58:47.581-04:002012-07-09T01:58:47.581-04:00Yes, does rare mean rare among humans in general, ...Yes, does rare mean rare among humans in general, or just rare among the ethnic groups included in the sample? Whichever it is, more extensive sampling would have been required in order to tell.5371noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-86266291134532173352012-07-09T00:09:49.687-04:002012-07-09T00:09:49.687-04:00Would be interesting to see East or Central Asians...Would be interesting to see East or Central Asians plotted on this, seeing as how far off from everyone else Northern Europeans and the Finnish are pulled away from the rest of Europe.Miley Cyraxnoreply@blogger.com