tag:blogger.com,1999:blog-5880610.post5409743073262273718..comments2024-01-13T18:57:18.243-05:00Comments on Information Processing: Genetic engineering of monkeys using CRISPRSteve Hsuhttp://www.blogger.com/profile/02428333897272913660noreply@blogger.comBlogger15125tag:blogger.com,1999:blog-5880610.post-86081343000525644582014-02-04T22:09:49.132-05:002014-02-04T22:09:49.132-05:00Thanks for the link. But back to my original point...Thanks for the link. But back to my original point, myopia therefore can be eliminated and IQ not negatively impacted provided the correct genetic makeup put in its place. Mental capabilities need not come at the expense of physical ailment.willnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-13924416888820386012014-02-04T11:37:09.627-05:002014-02-04T11:37:09.627-05:00You say that there is slim evidence of your IQ inc...You say that there is slim evidence of your IQ increasing that much merely by studying, but what about high IQ folks just reading more and causing eye problems? Just curious. Thanks.Michael Baconnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-70767995790295890352014-02-03T01:50:48.029-05:002014-02-03T01:50:48.029-05:00If the overlap wasn't perfect, you could still...If the overlap wasn't perfect, you could still have gifted people without visual impairment.<br /><br /><br />This is where a bivariate GCTA analyis would be helpful: http://infoproc.blogspot.no/2013/09/pleiotropy-g-and-specific-learning.html (Finding out for sure is more fun than discussing on the internet.)Endre Bakken Stovnernoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-46368296942097775172014-02-02T18:45:55.417-05:002014-02-02T18:45:55.417-05:00Therefore myopia is incidentally associated with p...Therefore myopia is incidentally associated with particular genetic makeup that cause IQ but not necessarily so.willnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-63358795566512388742014-02-02T18:44:37.827-05:002014-02-02T18:44:37.827-05:00How is it then that many geniuses and many High IQ...How is it then that many geniuses and many High IQ people manage to not have the refractive error of myopia? If that is so. Then Myopia can be eliminated without impacting IQ.willnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-36807897681097303562014-02-02T12:18:13.239-05:002014-02-02T12:18:13.239-05:00There can certainly be synergistic effects, but th...There can certainly be synergistic effects, but there are very good reasons for believing it to be partly explained by genetic overlap.<br /><br />A from the top of my head rebuttal would be that there are many other reasons a person might be less socially active or play much, for example being born into or having to use a wheelchair from a young age. If the folk explanation for the overlap Endre Bakken Stovnernoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-18508880612030018562014-02-02T11:01:31.177-05:002014-02-02T11:01:31.177-05:00Are these relations truly genetic, or just cultura...Are these relations truly genetic, or just cultural artifacts? A folk explanation in both cases is that a kid with asthma or poor eyesight is less likely to be playing sports or scouting outdoors etc., and later less active on the dating scene, and will thus have more time to read, study, and think, and will tend to socialize with other kids of similar interests.Anonymous_IVnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-37559513500194884842014-02-02T09:04:03.402-05:002014-02-02T09:04:03.402-05:00You wouldn't want that. IQ and nearsightedness...You wouldn't want that. IQ and nearsightedness are genetically overlapping phenomena. See Cohn, Cohn and Jensen: http://www.ncbi.nlm.nih.gov/pubmed/3417304 IIRC they tested within-famliy correlation between IQ and myopia in sixty sibling pairs and found highly significant results.<br /><br />There are more recent reviews, but pubmed wasn't good to me on this Sunday morning.<br /><br /><brEndre Bakken Stovnernoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-27447682085580270002014-02-01T12:42:02.855-05:002014-02-01T12:42:02.855-05:00If they see no off-targets in 5% (exomes) of the g...If they see no off-targets in 5% (exomes) of the genome then (assuming uniform probability of random cutting), there might be ~ 10 at most in the rest of the genome -- it depends on how many individuals they did the exomes for. If you did, e.g., 20 individuals and found no off-targets on their exomes then you would be pretty confident that off-target probability is really small. IIUC, in the steve hsuhttp://duende.uoregon.edu/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-21053102801595730962014-02-01T12:24:43.506-05:002014-02-01T12:24:43.506-05:00"exome sequencing analysis showed that no off..."exome sequencing analysis showed that no off-target mutations were induced" <br /><br />So, they are looking at only 5% of the genome... I.e., if the ratio is 1:10, they can't detect it. They also excluded excess point mutations and have done it completely arbitrarily: "Because engineered nucleases rarely induce substitutions via error-prone NHEJ". The reference is DKnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-65598609803957462092014-02-01T09:08:09.848-05:002014-02-01T09:08:09.848-05:00This lab is, I believe, in Kunming. They don't...This lab is, I believe, in Kunming. They don't have the same issues we have here ...steve hsuhttp://duende.uoregon.edu/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-6197108545924479722014-02-01T08:38:16.261-05:002014-02-01T08:38:16.261-05:00What do you think of this paper?
http://www.ncbi....What do you think of this paper?<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/24253446<br /><br />"Here, we show that off-target effects of RGENs can be reduced below the detection limits of deep sequencing by choosing unique target sequences in the genome and modifying both guide RNA and Cas9. ... Our results highlight the importance of choosing unique target sequences and optimizing guidesteve hsuhttp://duende.uoregon.edu/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-28550210494975239782014-02-01T08:23:23.692-05:002014-02-01T08:23:23.692-05:00While I share DK's reservations, I hope the au...While I share DK's reservations, I hope the authors and their institution have installed proper security for both the laboratory and the researchers and staff. This sort of thing will incense animal rights activists and environmentalists, and they will at some point launch a violent attack on the facilities and people involved.BobSykesnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-53716665269294090152014-02-01T03:19:16.769-05:002014-02-01T03:19:16.769-05:00Awesome. Myopia may be wiped entirely from the gen...Awesome. Myopia may be wiped entirely from the gene pool.willnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-87576085693708549022014-01-31T21:55:34.298-05:002014-01-31T21:55:34.298-05:00no off-target mutagenesis was detected by comprehe...<i><b>no off-target mutagenesis was detected by comprehensive analysis</b></i><br /><br /><br />I was about to write "wow, amazing, how is it even possible and yes, I was dead wrong on this" but then opened up the actual paper. And I am afraid that this is the case of a fundamental lack of basic understanding how enzymes (and DNA-modifying enzymes in particular) work. From the methods: DKnoreply@blogger.com