tag:blogger.com,1999:blog-5880610.post5214633153912175400..comments2024-01-13T18:57:18.243-05:00Comments on Information Processing: What is medicine’s 5 sigma?Steve Hsuhttp://www.blogger.com/profile/02428333897272913660noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-5880610.post-21453856748517749202015-07-26T14:13:20.841-04:002015-07-26T14:13:20.841-04:00Somewhat related: http://www.nature.com/news/repro...Somewhat related: http://www.nature.com/news/reproducibility-don-t-cry-wolf-1.17859<br /><br />(On false claims in Physics.) Despite this, I agree that the biomedical literature is in poor shape, though I'd claim the problem is much more due to a lack of understanding of what things like p-values mean than a lack of sufficiently stringent "significance" criteria.Raghuveer Parthasarathyhttp://eighteenthelephant.wordpress.com/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-75831099145958096782015-07-22T08:14:49.801-04:002015-07-22T08:14:49.801-04:00We live in a Lysenkoist age. Academic researchers ...We live in a Lysenkoist age. Academic researchers in particular are under pressure and are rewarded to produce the results desired by their researcher sponsors, who are mostly highly politicized government agencies. It should be noted that unlike industrial researchers, academics are almost entirely unsupervised and unmonitored. They are hired and promoted based on their ability to bring in BobSykesnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-34389704275806260372015-07-21T19:05:55.738-04:002015-07-21T19:05:55.738-04:00The scientific literature itself has its problems,...The scientific literature itself has its problems, but the real issue is the transition to medical practice. Everybody who's ever looked seriously at the issue, from the US Congress Office of Technology Assessment, to the BMJ, to the Cochrane, finds no more than 10-30% of medical practice is supported by scientific research. The Mayo Clinic just looked at studies testing an implemented changeNat Philosopherhttp://whyarethingsthisway.com/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-2046010841838782362015-07-21T06:51:12.182-04:002015-07-21T06:51:12.182-04:00>> I don't think that the history of gen...>> I don't think that the history of genetic associations that you present to Ioannidis is correct. I believe that there was a period of GWAS with correction for multiple comparisons that still failed to replicate before the current period of replication. <<<br /><br /><br />I'm not aware of this history you reference, but I am only a recent entrant into this field. On the steve hsuhttp://plus.google.com/u/0/+StephenHsu/aboutnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-17872520483516775472015-07-20T22:41:50.257-04:002015-07-20T22:41:50.257-04:00I don't think that the history of genetic asso...I don't think that the history of genetic associations that you present to Ioannidis is correct. I believe that there was a period of GWAS with correction for multiple comparisons that still failed to replicate before the current period of replication. I think that this was a period of very few hits per paper, which was probably should have been a warning sign.<br /><br />Also, I am disturbedDouglas Knightnoreply@blogger.com