tag:blogger.com,1999:blog-5880610.post3351415065265485605..comments2024-01-13T18:57:18.243-05:00Comments on Information Processing: @Google: Genetics and IntelligenceSteve Hsuhttp://www.blogger.com/profile/02428333897272913660noreply@blogger.comBlogger80125tag:blogger.com,1999:blog-5880610.post-57015769357991840902012-01-19T23:44:58.135-05:002012-01-19T23:44:58.135-05:00Not sure why the Disqus spam filter grabbed your c...Not sure why the Disqus spam filter grabbed your comment. But I've now released it.steve hsuhttp://duende.uoregon.edu/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-30222725305047221302012-01-19T23:40:04.124-05:002012-01-19T23:40:04.124-05:00Steve,
Are open discussions allowed on your blog? ...Steve,<br />Are open discussions allowed on your blog? I felt compelled to comment on this study of intelligence and posted some points on what I felt was an incongruence with your intended study of intelligence and the qualifying criteria listed, yesterday, but post seemed to have been deleted.<br /><br />A reply would be appreciated.Mike Chewhttp://www.facebook.com/people/Mike-Chew/100000417909659noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-76234421945962099282011-08-27T04:24:02.377-04:002011-08-27T04:24:02.377-04:00Hmm, I could swear I made a response to this, but ...Hmm, I could swear I made a response to this, but it's not visible any more?<br /><br />Anyway. Have you ever heard of the protein domain DUF1220? This is a protein domain of unknown function that is encoded independently by at least 30 and possibly over 60 different genes (some of them also do it multiple times); it's highly specific to humans (we have 6 times the number of copies of esmithnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-86773224964178862812011-08-27T03:00:05.480-04:002011-08-27T03:00:05.480-04:00But a surprisingly large part of those 25k is resp...But a surprisingly large part of those 25k is responsible for brain development or functioning of the nervous system. There was an article a few years ago that estimated that 58% of human transcriptome is expressed in brains of at least 5% of humans. The human brain map at http://human.brain-map.org identifies around 1000 genes which may be relevant here.esmithnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-77835268067344436492011-08-26T18:33:42.808-04:002011-08-26T18:33:42.808-04:00I thought humans had only 25k genes. 1000 relate ...I thought humans had only 25k genes. 1000 relate to intelligence? That seems a lot. Our bodies have a lot going on other than g-related activity.efalkennoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-55910598925586786592011-08-25T11:16:37.882-04:002011-08-25T11:16:37.882-04:00I've received an email finally -- thanks.I've received an email finally -- thanks.William_JDnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-35499317938632198872011-08-25T11:04:45.169-04:002011-08-25T11:04:45.169-04:00After you've entered your email address on the...After you've entered your email address on the volunteer page once, any further submits don't send additional emails. Check your spam filter on the day you first tried to submit.Christopher Changhttp://www.facebook.com/profile.php?id=723726480noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-10938950138551461062011-08-25T09:46:00.837-04:002011-08-25T09:46:00.837-04:00On the "Volunteer" page, when I enter my...On the "Volunteer" page, when I enter my email address and click submit, I receive the following message: "Check your email for instructions." It's been a week since I submitted my email address, and I have yet to receive any instructions. When can I expect them?William_JDnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-51638492956773105732011-08-23T09:55:11.647-04:002011-08-23T09:55:11.647-04:00"Then we should be able to construct an "..."Then we should be able to construct an "intelligence measure" equal to the share of positive alleles among these N, which correlates linearly with physically measurable quantities."<br /> <br />If you wanted to, but there'd still be a bell shaped curve.<br /> <br />"It means that the person at +3 SD would only be 10-15% better/faster on any such test."<br /> <brMtMorunoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-12863210478139180432011-08-22T23:02:28.566-04:002011-08-22T23:02:28.566-04:00On the second thought, that high end behavior is E...On the second thought, that high end behavior is EXACTLY what we should expect ... Suppose that we break down the time to execute a task into N pieces, and time to execute each piece depends on a single gene, and total time is a simple sum of all pieces. Having a few "strong" genes which can significantly reduce the processing time, and a lot of "weak" genes, each of which esmithnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-61041205581395108532011-08-22T20:48:04.495-04:002011-08-22T20:48:04.495-04:00Are you aware of any studies that quantify the rel...Are you aware of any studies that quantify the relationship between processing speed and IQ? (Preferably the problem-solving processing speed, and not things like reaction time.) I'm trying to quantify it, and I'm getting curious results (see image). The huge dynamic range leads me to suspect that the mean frequency of IQ-positive alleles is very low (maybe 10-20%). But it's hard to esmithnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-149640341880023452011-08-22T18:20:17.353-04:002011-08-22T18:20:17.353-04:00The model in the slides is just a toy model to ill...The model in the slides is just a toy model to illustrate scaling. In reality there will be distributions in effect sizes and allele frequencies in a particular population. See the height results which are starting to flesh this out for a different quantitative phenotype.steve hsuhttp://duende.uoregon.edu/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-76946065882358359232011-08-22T18:12:46.149-04:002011-08-22T18:12:46.149-04:00The simplifying assumptions in that slide are made...The simplifying assumptions in that slide are made purely to allow the relevant point to be made with a minimum of complications. The assumptions themselves should not be taken too seriously.<br /><br />There is a <a href="http://www.amazon.com/Genetics-Analysis-Quantitative-Traits-Michael/dp/0878934812/" rel="nofollow">quantitative-genetic literature</a> on the estimation of gene number. To James Leenoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-79315863752700409232011-08-22T17:07:31.290-04:002011-08-22T17:07:31.290-04:00I was thinking about prospects of genetic engineer...I was thinking about prospects of genetic engineering (what would a person with all IQ genes turned on look like?) and estimates on page 28 of the slides made me realize something.<br /><br />It assumes that intelligence is determined by many (10^3) genes of equal small effect. But it can't work like that! Either the number N must be much smaller, or some genes are significantly more esmithnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-51922360103971365532011-08-21T19:31:00.363-04:002011-08-21T19:31:00.363-04:00A case-control design that relies on volunteers to...A case-control design that relies on volunteers to fill out the case group cannot get around this problem. There will need to be replication in other designs that do not suffer from this flaw.James Leenoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-27586588183105416592011-08-21T19:28:04.115-04:002011-08-21T19:28:04.115-04:00Your genetic data will probably never provide as m...Your genetic data will probably never provide as much information about your phenotype as measurements of the phenotype itself. If you want to know how fast you are, use a stopwatch; don't bother to measure your ACTN3 genotype. That said, even elite athletes often *are* curious about their ACTN3 genotype, and there seems to be no harm in allowing that itch to be scratched. <br /><br />James Leenoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-43408226323203708072011-08-21T14:17:44.004-04:002011-08-21T14:17:44.004-04:00I'm interested in the answer to point #1.. On ...I'm interested in the answer to point #1.. On that note, what if you have a curiosity gene, which made you want to be a case? <br /> Or a teaching gene that made you want to be in a PhD program? Anything<br /> that separates the case group from smart people as a whole could <br />confound the study.ben_gnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-40178588809265789692011-08-21T04:07:13.232-04:002011-08-21T04:07:13.232-04:00The discrepancy between the trait prediction and y...The discrepancy between the trait prediction and your actual phenotype is an (increasingly noisy, as the relative contribution of environment increases) estimator of how much is still unknown about your genome.Christopher Changhttp://www.facebook.com/profile.php?id=723726480noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-79923851209092409942011-08-20T23:52:41.537-04:002011-08-20T23:52:41.537-04:00I'm an automatic, but in the consent form ther...I'm an automatic, but in the consent form there's this: <i>At an advanced stage of the study, BGI-CGL may provide you access to your genetic data and interpretations thereof with respect to ancestry, disease risk, and predicted trait levels (including level of cognitive ability).</i> Is that estimate of cognitive ability for the non-automatics only. If not there's a huge problem.MtMorunoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-75410604852506153352011-08-20T23:40:31.844-04:002011-08-20T23:40:31.844-04:00I'm an automatic, but in the consent form ther...I'm an automatic, but in the consent form there's this: <br /><i>At an advanced stage of the study, BGI-CGL may provide you access to your genetic dataand interpretations thereof with respect to ancestry, disease risk, and predicted trait levels(including level of cognitive ability).</i>Is that estimate of cognitive ability for the non-automatics only. If not there's a problem. If youMtMorunoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-33675484650939961982011-08-20T15:31:55.306-04:002011-08-20T15:31:55.306-04:00My brother makes the cutoff. Alas, I do not. Le ...My brother makes the cutoff. Alas, I do not. Le sigh.<br /><br />...but mama says i'm good at other stuff...! I can draw real good.TheGuyFromEarliernoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-15603960790849231632011-08-20T10:54:43.223-04:002011-08-20T10:54:43.223-04:00We cannot give many additional details regarding t...We cannot give many additional details regarding the design of this study (or others we are carrying out) for several reasons. One is that our potential and actual collaborators may not want to be disclosed at the moment.James Leenoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-40773499521247421412011-08-20T00:01:16.600-04:002011-08-20T00:01:16.600-04:00Not quite. The gre-m is taken by college students...Not quite. The gre-m is taken by college students applying to graduate school. So that means that those taking the test not only got into college, but then had higher than average gpa's there. So it may be closer to a 2.5+ for the math. You need to account for the fact that those applying to grad school probably have an average iq of 110 at least. Well, hopefully.whatisgoingon whatisgoingonnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-2417828178255100552011-08-19T23:17:45.979-04:002011-08-19T23:17:45.979-04:00Aww. 800 math, 800 math 2,800 physics,740 verbal
...Aww. 800 math, 800 math 2,800 physics,740 verbal<br /><br />Damn, so close. I guess I have to wait for graduate school.whatisgoingon whatisgoingonnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-49459316811820141152011-08-19T22:53:40.208-04:002011-08-19T22:53:40.208-04:00We will count your most recent score.We will count your most recent score.James Leenoreply@blogger.com