tag:blogger.com,1999:blog-5880610.post1186763459285620488..comments2024-01-13T18:57:18.243-05:00Comments on Information Processing: Fifty years of twin studiesSteve Hsuhttp://www.blogger.com/profile/02428333897272913660noreply@blogger.comBlogger20125tag:blogger.com,1999:blog-5880610.post-46946778850946159952015-07-21T06:52:43.785-04:002015-07-21T06:52:43.785-04:001. Perhaps it depends on the trait?
2. Perhaps it ...1. Perhaps it depends on the trait?<br />2. Perhaps it is a typo?steve hsuhttp://plus.google.com/u/0/+StephenHsu/aboutnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-80126728884096311052015-07-21T00:40:55.367-04:002015-07-21T00:40:55.367-04:00Will you see a comment on this old post? I'm ...Will you see a comment on this old post? I'm working my way through the paper, and I found this: <br /><br />"The data showed a decrease in monozygotic and dizygotic twin resemblance after adolescence and an accompanying decrease in the estimates of both h2 and c2"<br /><br /><br /><br />I had thought that traits generally became *more* heritable with age. This indicates I'm Bobwnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-28017895731509908472015-06-02T08:19:53.326-04:002015-06-02T08:19:53.326-04:008. Whoops, I didn’t respond to one of your studies...8. Whoops, I didn’t respond to one of your studies, the<br />GTCA. That doesn’t mean anything. When you indiscriminately look at half a<br />million of SNPs, you’re bound to hit on things like skin color, or<br />left-handedness, or height, and so on. These could all be things that<br />indirectly affect IQ through the mechanics of society, i.e. they’re directly environmental,<br />but they’re nslewisnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-28104386773530800702015-06-01T15:57:28.679-04:002015-06-01T15:57:28.679-04:00testtestWillienoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-23913527977327847302015-05-29T04:52:38.931-04:002015-05-29T04:52:38.931-04:00Zygosity determination using questionnaires is hig...Zygosity determination using questionnaires is highly reliable, see <a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8494873&fileId=S1369052300003809" rel="nofollow">here</a> and <a href="http://www.researchgate.net/profile/Ian_Craig/publication/12287905_Infant_zygosity_can_be_assigned_by_parental_report_questionnaire_data/links/00b7d5176b6b62ede5000000.Willienoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-32084522163208148572015-05-28T08:04:41.063-04:002015-05-28T08:04:41.063-04:00So what happens in another few years when somebody...<i>So what happens in another few years when somebody thinks of some more aspects to include in an analysis? That “modest” could rise to “huge.”</i><br /><br />Across the last few decades, a large number of studies using different approaches have tried to find violations of the equal environments assumption, but while small violations are possible, there is simply no evidence for "huge"Willienoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-1383539979780903632015-05-27T19:39:50.245-04:002015-05-27T19:39:50.245-04:00A nice shotgun scattershot of studies, all saying ...A nice shotgun scattershot of studies, all saying different things, or maybe saying the same thing: tweak a statistical model and you get hugely different results. <br /><br />The first link that you provide tells me that a study done some 40 years ago, which is supposed to say that the equal environment assumption is bulletproof, does not in fact say that it’s bulletproof, once you start to looknslewisnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-28088075316379226592015-05-27T08:13:29.052-04:002015-05-27T08:13:29.052-04:00There's been lots of attempts to invalidate th...There's been lots of attempts to invalidate the equal environments assumption between DZ and MZ pairs, but the assumption has been <a href="http://www.sciencedirect.com/science/article/pii/S0049089X13001397" rel="nofollow">shown</a> to hold up well.<br /><br />On the other hand, to the extent that genetic differences cause people to be selected into different environments that cause further Willienoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-6462961142002530472015-05-25T20:10:25.513-04:002015-05-25T20:10:25.513-04:00Oh, very good. I am very much a neophyte when it c...Oh, very good. I am very much a neophyte when it comes to analysis. I attempted to run my results through one of the suggested tools and got some VERY questionable ethnicity results (like, the wrong continent). I'll assume I was doing it wrong.Apollonoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-53203253860361782362015-05-23T09:53:43.965-04:002015-05-23T09:53:43.965-04:00I've been using Promethease for analysis. Wit...I've been using Promethease for analysis. With the QC criteria BGI is using my WGS only gave a bit more than 1/3 as many Promethease SNPs as a 23andMe chip though. I asked for a VCF file to be uploaded as well which will have lower confidence calls. It's expected in a few months. There is some brief discussion about analysis at LessWrong: http://lesswrong.com/lw/7wj/Richard Seiternoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-21763796923317891832015-05-23T00:45:19.409-04:002015-05-23T00:45:19.409-04:00now i'm thinking steve is so retarded that whe...now i'm thinking steve is so retarded that when he doesn't catch his white whale he'll make it up.<br /><br />local h^2 figures say absolutely nothing about global h^2 for any trait.<br /><br />or steve will just go completely bonkers.<br /><br />he's well on his way there.steve is a moronnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-70557695196622552812015-05-23T00:41:34.644-04:002015-05-23T00:41:34.644-04:00Ah, were those 4x coverage results we received? I ...Ah, were those 4x coverage results we received? I wasn't aware. How deep will the deeper coverage results be?<br /><br />Have you found any particularly good tools for analysis?Apollonoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-28561390774920089952015-05-22T23:11:18.731-04:002015-05-22T23:11:18.731-04:00Fulltext: https://www.dropbox.com/s/ekxxlubswlry14...Fulltext: https://www.dropbox.com/s/ekxxlubswlry14k/2015-polderman.pdf / http://sci-hub.org/downloads/2575/10.1038@ng.3285.pdfgwernhttp://www.gwern.net/noreply@blogger.comtag:blogger.com,1999:blog-5880610.post-53759421949049255792015-05-22T14:05:20.597-04:002015-05-22T14:05:20.597-04:00Yes! I was excited when you posted on that before...Yes! I was excited when you posted on that before (but was the sole commenter) at http://infoproc.blogspot.com/2014/08/determination-of-nonlinear-genetic.html<br /><br />Has there been any follow up work that could assess how often the nonlinearities matter? Would it be possible to try replicating the endurance athletes work using your algorithms? (thinking about it more, the sample size is Richard Seiternoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-89759577917416159352015-05-22T13:46:05.471-04:002015-05-22T13:46:05.471-04:00> I worry about naive use of purely additive mo...> I worry about naive use of purely additive models <<br /><br />http://arxiv.org/abs/1408.6583steve hsuhttp://plus.google.com/u/0/+StephenHsu/aboutnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-60423821720927068322015-05-22T13:33:18.376-04:002015-05-22T13:33:18.376-04:00I am very interested in seeing if there turn out t...I am very interested in seeing if there turn out to be significant non-additive effects. It seems clear that there should be cases where there is nonlinearity (e.g. single allele is relatively minor loss of function or even advantageous, but homozygous is severely detrimental or even fatal). A common example of this is the sickle cell allele. I think it's safe to say there are likely to beRichard Seiternoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-7826832903373692002015-05-21T22:34:09.331-04:002015-05-21T22:34:09.331-04:00Perfect. Thanks.Perfect. Thanks.Bobwnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-61933729694039736702015-05-21T21:58:10.996-04:002015-05-21T21:58:10.996-04:00e.g., http://www.nature.com/nrg/journal/v13/n9/box...e.g., http://www.nature.com/nrg/journal/v13/n9/box/nrg3243_BX2.htmlsteve hsuhttp://plus.google.com/u/0/+StephenHsu/aboutnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-40135504986016498492015-05-21T21:39:32.708-04:002015-05-21T21:39:32.708-04:00On a lighter note, there is a documentary called &...On a lighter note, there is a documentary called "Twinning" that is set to be released this year, about a set of twenty-something Korean identical twins. One was raised in France, the other in California; neither knew of the other's existence until they found each other on Youtube. Like other identical twins, they are probably uncannily similar in a host of ways, but of course this aseussnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-76967436113096071942015-05-21T20:01:54.431-04:002015-05-21T20:01:54.431-04:00A request for info. I think I generally understan...A request for info. I think I generally understand how twin studies sort out the magnitudes of (genes + shared env + other). However, I *don't* understand how these studies exclude non-linear genetic interactions. Nor epigenetic effects for that matter.<br /><br /><br />I understand that the "other" category in these studies is surprisingly (to me, at least) large. Wouldn't Bobwnoreply@blogger.com