tag:blogger.com,1999:blog-5880610.post1114682138677836362..comments2024-01-13T18:57:18.243-05:00Comments on Information Processing: Genetic architecture and predictive modeling of quantitative traitsSteve Hsuhttp://www.blogger.com/profile/02428333897272913660noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-5880610.post-76478617208695350302015-07-26T20:37:26.127-04:002015-07-26T20:37:26.127-04:00Oh. Dang. Never mind. Reading the plot upside-d...Oh. Dang. Never mind. Reading the plot upside-down.Bobwnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-74158048398107746072015-07-26T20:31:08.122-04:002015-07-26T20:31:08.122-04:00OK, that's how I originally thought about it. ...OK, that's how I originally thought about it. However, as I said above, that region of the graph holds effects *larger* than effects detected at *lower* frequency. It's like this: If an effect of this magnitude were only *rarer*, we could detect it. Since it's so common, however, we can't. <br /><br />That region should be the easiest to work with: Moderate effect, moderateBobwnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-25843911504776066182015-07-26T17:45:39.834-04:002015-07-26T17:45:39.834-04:00If frequency is too low then in a given sample of ...If frequency is too low then in a given sample of individuals you won't have very many people who have the variant, so your ability to say something about it is limited. Of course if the effect size is large enough (i.e., makes people +1 foot taller) you might detect it from just a few cases. So you can see these things trade off against each other.steve hsuhttp://plus.google.com/u/0/+StephenHsu/aboutnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-2742012633374916842015-07-26T13:46:51.629-04:002015-07-26T13:46:51.629-04:00Hi Steve. Sorry. Dude keeps asking questions on ...Hi Steve. Sorry. Dude keeps asking questions on old topics.<br />That empty ellipse on slide 10 (frequency vs effect magnitude). I'm trying to reason why that is empty. The math detects smaller effect sizes that that. It detects smaller frequencies than that. Why is it empty? Under selection, I reasoned that all moderate-magnitude alleles would get either pushed towards fixation or Bobwnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-50254137551223893402015-07-20T01:05:31.619-04:002015-07-20T01:05:31.619-04:00Thanks so much, Steve. That was awesome. I had q...Thanks so much, Steve. That was awesome. I had questions as I watched it, but now I can't remember them. I guess I'll have to watch it again.Bobwnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-85145737146769034712015-05-25T11:58:54.562-04:002015-05-25T11:58:54.562-04:00Tell it to the bored.Tell it to the bored.lukeleanoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-73209459655122133452015-05-25T11:54:13.037-04:002015-05-25T11:54:13.037-04:00About that 25 SD -- isn't it possible that the...About that 25 SD -- isn't it possible that there might be diminishing returns as more and more of those negative alleles are eliminated? Is that inconsistent with the idea of additivity?lukeleanoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-55421658584084388362015-05-25T01:30:32.468-04:002015-05-25T01:30:32.468-04:00There are always new challenges.There are always new challenges.ben_gnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-28642459061088646692015-05-24T20:42:23.673-04:002015-05-24T20:42:23.673-04:00Very good. You are a natural teacher. One questi...Very good. You are a natural teacher. One question though: would -- or, rather, might -- people with cognitive abilities +25SD find the world a boring place to be? The game of life would be too easy.lukeleanoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-22906419139850085262015-05-23T12:52:30.904-04:002015-05-23T12:52:30.904-04:00I've been puzzling over how best to do slide d...I've been puzzling over how best to do slide decks with audio. I did the Udacity course on massively parallel computing [i.e. GPU computing], and I liked the way that they incorporate writing into it, but they don't also use static slides. Plus, sometimes the act of drawing is important to the description [especially when trying to illustrate dynamic concepts]. Have you tried that?David Coughlinnoreply@blogger.comtag:blogger.com,1999:blog-5880610.post-75739462243725934052015-05-22T17:24:18.750-04:002015-05-22T17:24:18.750-04:00Steve, don't know if you know about using dl.d...Steve, don't know if you know about using dl.dropbox.com in your link as a way of allowing direct download of the file. I find that handy. For example:<br />https://dl.dropbox.com/s/tjsdre0u3hvca0x/NIH-HLI.pdf?dl=0<br />For PDFs it's not that big of a deal, but the direct link is much nicer for HTML files.<br /><br />Thanks for the slides and talk! I like your slide 16 visual (in the Richard Seiternoreply@blogger.com